Advanced materials: an alternative to natural enzymes: highly effective tumor therapeutic nanodrugs based on rare earth cerium based nanomaterials

enzyme is an indispensable substance for the normal operation of human function has important application value in the treatment of many diseases. However the high production cost difficult preservation of natural enzyme greatly limit its further application in the field of medicine. Nano catalytic therapy based on nano scale artificial enzyme mimics (nano enzyme) is an emerging technology for the treatment of various malignant tumors. However the catalytic activity of nanoenzymes in tumor microenvironment is still relatively insufficient. In order to solve this problem Professor Yang Piaoping of Harbin Engineering University researcher Lin Jun of Changchun Institute of Applied Chemistry Chinese Academy of sciences have developed a bacterial like cerium based nanoenzyme (PEG)/ Ce-Bi@DMSN )The nanoenzyme has dual enzyme mimic catalytic activities (peroxidase like catalase like activities) glutathione consumption under local photothermal regulation It can produce reactive oxygen species in tumor tissue achieve efficient tumor treatment. Using bismuth sulfide nanorods cetyltrimethylammonium chloride (CTAC) as hard soft templates

were synthesized in an oil-water two-phase system to synthesize bacterial nano platforms with adjustable thickness large pore size then loaded with ultra-small CeO2 nanoenzymes (higher Ce3 / Ce4 ratio: 1.94 / 1) synthesized by an improved reverse micelle method. At the same time due to the existence of bismuth sulfide nanorods the enzyme showed a good photothermal conversion efficiency (36.2%) under 1064 nm laser irradiation which could achieve the function of photothermal response. The nanozyme showed dual enzyme mimic catalytic activities (peroxidase like catalase like) under slightly acidic conditions which could effectively regulate the tumor microenvironment that is increase oxidative stress alleviate the resistance of tumor cells to reactive oxygen species caused by hypoxia. In addition the nanoenzyme can effectively consume the over expressed glutathione (GSH) in tumor cells through redox reaction. It is worth noting that the two enzyme activities GSH depletion ability of the nanoenzyme were improved under local photothermal environment. It provides a prerequisite for specific treatment in response to tumor microenvironment stimulation.

can be confirmed by biological anti-tumor experiments in vitro in vivo/ Ce-Bi@DMSN Nano enzyme can realize heat enhanced nano catalytic tumor therapy which has obvious effect on tumor inhibition. In general the concept of thermally enhanced multiple enzyme activity based on nano enzyme materials proposed in this work provides a new idea practical application strategy for efficient tumor treatment. The researchers of

believe that this research will provide new ideas for the efficient treatment of tumor based on nano materials.

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