Small: defects make quantum dots produce efficient sterilization properties independent of light

The infection caused by

bacteria is the main cause of clinical inflammation which seriously threatens human health. The invention application of antibiotics have brought us into the period of infection control for nearly a century. However the wide application of antibiotics has also prompted bacteria to gradually evolve corresponding drug resistance making the effectiveness of existing antibiotics gradually weaken. Taking the treatment of ophthalmic inflammation as an example moxifloxacin other antibiotics can only be used for the treatment of bacterial keratitis at present. However moxifloxacin resistant strains have been observed in the world in less than 20 years since the beginning of the 21st century the number is still rising. Therefore it is urgent to develop new fungicides to solve the increasingly serious problem of drug-resistant bacteria infection.

Shong University research team used ion irradiation technology to modify transition metal sulfide (xs2x = Mo / W) quantum dots to produce light independent highly effective bactericidal properties tried to use them in the treatment of ocular inflammation caused by drug-resistant bacteria. In the process of ion irradiation the sulfur atoms on the top layer of XS2 are sputtered to form a defect structure (sulfur vacancy) which makes XS2 quantum dots have strong oxidation. Under the condition of room temperature dark light the sterilization rate of ws2-0.1 quantum dots (140 μ g / ml) against gram-positive Staphylococcus aureus methicillin-resistant Staphylococcus aureus (MRSA) can reach more than 99.9% within 20 minutes. Based on the charge transfer ability of ws2-0.1 quantum dots they discussed the antibacterial mechanism. On the one h the defects produce more surface electronic states which increases the surface charge transport; On the other h the physical contact between microbial membrane (higher Fermi surface similar to n-type semiconductor) ws2-y quantum dots (lower Fermi surface similar to p-type semiconductor) forms p-n-like junctions which only allows unidirectional electron transport (cell membrane → quantum dots). Therefore ws2-y quantum dots exhibit strong oxidative stress properties independent of reactive oxygen species.

this study shows that ion beam irradiation defects can modify quantum dots to produce new bactericidal properties which provides a new idea for the development of new nano drugs.

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