• 0
  • 0

Advanced materials: reversing fate: piezoelectric composite nanoparticles regulate neural plasticity and restore neuronal function

If you are looking for high-quality products, please feel free to contact us and send an inquiry, email:

Parkinson's disease is a common neurodegenerative disease in middle-aged elderly people. The main pathological change is the degeneration death of dopaminergic neurons in substantia nigra. Therapeutic solutions include drug therapy gene therapy cell transplantation cell reprogramming so on; there are still great challenges in developing non-invasive simple but effective strategies to restore the function of endogenous dopamine neurons.

electromagnetic fields are an indispensable part of the life system. They affect intracellular communication neuronal activity ion transport thus affecting cell migration proliferation differentiation even reprogramming cells. Piezoelectric nanomaterials can easily respond to external stimuli convert mechanical energy into electrical energy which is a promising tool for remote non-invasive precise neural regulation. Due to its unique energy conversion properties piezoelectric nanomaterials have broad application prospects in biomedicine such as multi-stage carriers in nanodrugs in vivo imaging probes nanoscale transducers to induce cell growth / differentiation. Nanomaterials with higher electric coefficient electromechanical coupling coefficient have high efficiency in electromagnetic field generation. Ultrasound can be used to generate electromagnetic fields through remote control of piezoelectric nanoparticles.

Shen qundong Department of polymer science engineering School of chemistry chemical engineering Nanjing University proposed the use of piezoelectric composite nanoparticles to regulate neural plasticity restore the function of degenerative dopaminergic neurons in vivo. The results show that the carbon shell with specific thickness on the surface of piezoelectric nanocrystals by hydrothermal method has good biocompatibility; its acoustic impedance is close to the biological medium the conduction loss is small the electronic polarization at the interface is enhanced so the core-shell nanoparticles show excellent ultrasonic absorption electromagnetic field generation performance in vivo. Under the ultrasonic pressure the charge separation of piezoelectric nanomaterials leads to the generation of potential. The potential changes periodically with the high frequency ultrasonic the electric stimulation intensity is enough to activate nerve cells.

combine core-shell piezoelectric nanoparticles with remote ultrasound to generate a controllable electric field which can realize remote electrical stimulation at the nano biological interface. Nanoparticles can generate electrical signals to transmit to nerve cells by receiving ultrasonic signals stimulate voltage dependent ion channels in nerve cells cause cell depolarization; at the same time nanoparticles can increase the expression of synaptophysin protein a marker of synaptic plasticity control zebrafish tail movement by regulating calcium influx in neural circuits. Dopamine is a neurotransmitter regulating the central nervous system. Tyrosine hydroxylase is the rate limiting enzyme of dopamine synthesis the key enzyme catalyzing the transformation of L-tyrosine to L-dopa. The electric field generated by piezoelectric nanoparticles activated the expression of tyrosine hydroxylase improved the movement disorder of zebrafish. The electromagnetic nanoparticles have good biological safety in brain tissue which provides a new idea for remote treatment of neurodegenerative diseases nerve regeneration.

MIS-ASIA is an online content marketing platform that has a large number of visitors worldwide. It is considered to be the leading IT, mechanical, chemical, and nanomaterial information distributor in the Asia-Pacific region. The MIS-ASIA website provides high-quality articles and news on digital information technology, mechanical technology, nanotechnology, biology and science for scientists, engineers and industry experts, machinery suppliers and buyers, chemical suppliers and laboratories. If you need advertising and posting service, or you need to start sponsorship, please contact us.

Inquiry us

  • tags

SCR Thyristor: Principles, Characteristics and Maintenance of Semiconductor Switches

High Purity Chromium Chip Chromium Sheet Chromium Flake CAS 7440-47-3,99.95%

Metal Alloy 8.92g/Cm3 High Purity Polished Copper Plate

Metal Alloy 18.5g/cm3 Polished Tungsten Heavy Alloy Plate

High Purity Antimony Sulfide Sb2S3 Powder CAS 1314-87-0, 99.99%

Metal Alloy 18g/cm3 High Density Tungsten Alloy Ball

High Purity Molybdenum Boride MoB2 Powder CAS 12006-99-4, 99%

High Purity Nano Hafnium Hf powder CAS 7440-58-6, 99%

Metal Alloy High Density Tungsten Alloy Rod Grind Surface Tungsten Alloy Bar

High Purity Germanium Sulfide GeS2 Powder CAS 12025-34-2, 99.99%

High Purity Chromium Diboride CrB2 Powder CAS 12007-16-8, 99%

High Purity Tungsten Silicide WSi2 Powder CAS 12039-88-2, 99%

High Purity Titanium Sulfide TiS2 Powder CAS 2039-13-3, 99.99%

High Purity 3D Printing Powder 15-5 Stainless Steel Powder

High Purity Nano Ag Silver powder cas 7440-22-4, 99%

High Purity Silicon Sulfide SiS2 Powder CAS 13759-10-9, 99.99%

High Purity Zirconium Nitride ZrN Powder CAS 25658-42-8, 99.5%

Supply Magnesium Granules Mg Granules 99.95%

High Purity 3D Printing 304 Stainless Steel Powder

High Purity Colloidal Silver Nano Silver Solution CAS 7440-22-4

Our Latest Products

SCR Thyristor: Principles, Characteristics and Maintenance of Semiconductor Switches

A brief introduction to thyristorsA thyristor is a powerful electronic device. It is a three-terminal component composed of four layers of PNPN semiconductor materials. Its forward working voltage is equal to the reverse breakdown voltage. This is re…

Metal Alloy 8.92g/Cm3 High Purity Polished Copper Plate

Copper products exhibit good electrical conductivity as well as thermal conductivity. They are also ductile, resistant to corrosion, and have a high wear resistance. They are widely used by the electricity, electronics and energy industries. Metal…

Metal Alloy 18.5g/cm3 Polished Tungsten Heavy Alloy Plate

Tungsten alloy heavy plate has low thermal expansion. It is also known for its high density, high radiation absorption, and high electrical and thermal conductivity. It is used widely in the aerospace and military industries. About Metal Alloy 18.5…