• 0
  • 0

View: black phosphorus -- a biodegradable two-dimensional material with multiple antitumor effects

Since its discovery

two-dimensional nanomaterials have been used in a variety of nano biomedical applications especially in anti-tumor therapy such as inhibiting cancer growth malignant migration multidrug resistance. Black phosphorus (BP) with two-dimensional lamellar structure not only has the characteristics of efficient photothermal conversion high photon singlet oxygen quantum yield but also has the large surface area of two-dimensional materials which can effectively load functional molecules for drug delivery biological imaging so that black phosphorus can be effectively applied to a variety of advanced anti-tumor therapies. Yu Xuefeng of Shenzhen Institute of advanced technology Chinese Academy of Sciences Qu Guangbo of ecological environment research center Chinese Academy of Sciences etc. summarized the application of black phosphorus in photothermal therapy (PTT) photodynamic therapy (PDT) chemotherapy (RT) active phosphorus therapy (BPT) drug delivery tumor treatment based on the anti-tumor research work of black phosphorus nanosheets (BPS) black phosphorus quantum dots (bpqds) in recent years The application of the integration of diagnosis treatment.

black phosphorus have good photothermal conversion efficiency which can increase the local temperature of the tumor by 30 degrees in a short time effectively use photothermal therapy to kill tumor cells. At the same time the excellent light excitation properties of black phosphorus make it have excellent application in photodynamic therapy. By using the good absorption conversion of black phosphorus to X-ray the X-ray can be converted into 1O2 to kill tumor. Combining the advantages of high light energy of X-ray photodynamic therapy of black phosphorus it can produce a large number of killer reactive oxygen species in tumor cells achieve the purpose of effective killing tumor cells. The two-dimensional structure of black phosphorus drug loading rate is also very high the drug loading rate can reach 98%. At the same time the photo thermal conversion ability of black phosphorus allows black phosphorus to degrade release in the near-infrared controlled high thermal environment which can achieve a controllable biodegradable drug delivery mode. If the black phosphorus is carried with fluorescent molecules or magnetic resonance imaging reagents the accurate imaging in the process of tumor treatment can be realized the function of tumor diagnosis treatment integration can be realized. However because black phosphorus itself is easy to degrade in the air or body environment some methods must be used to improve the stability of black phosphorus before using black phosphorus for the above treatment methods such as modifying some small molecules carrying metal particles using PLGA or polydopamine for surface coating so as to avoid degradation in the process of use affect the treatment effect. Yu Xuefeng's research team found that the degradation of black phosphorus material is selective in normal cells tumor cells. Due to the high metabolic activity rapid rate of tumor cells black phosphorus is more easily enriched in tumor cells. Reactive oxygen species produced by black phosphorus degradation promote tumor cells to produce inflammation cell cycle inhibition further induce apoptosis. The ability of black phosphorus to selectively kill tumor cells has been given a new name by Yu Xuefeng's team: biological therapy (BPT). Active phosphorus therapy is a kind of therapy which is produced by the degradation of black phosphorus which is different from other two-dimensional materials. At the same time the degradation product of black phosphorus is phosphoric acid which can not only participate in biomineralization but also participate in base synthesis protein phosphorylation so on. It has certain use in the body the specific effects still need to be further studied.

this review systematically describes the application of black phosphorus in a variety of tumor treatment technologies

MIS-ASIA is an online content marketing platform that has a large number of visitors worldwide. It is considered to be the leading IT, mechanical, chemical, and nanomaterial information distributor in the Asia-Pacific region. The MIS-ASIA website provides high-quality articles and news on digital information technology, mechanical technology, nanotechnology, biology and science for scientists, engineers and industry experts, machinery suppliers and buyers, chemical suppliers and laboratories. If you need advertising and posting service, or you need to start sponsorship, please contact us.

Inquery us

  • tags

Our Latest News

Global Silicon Nitride Si3N4 Powder,Overview of Silicon Nitride Si3N4 Powder,Silicon nitride Si3N4 powder application,The price of silicon nitride Si3N4 powder,Silicon Nitride Si3N4 Powder Supplier market trend 2025-2027 Product Characteristics and Applic

Silicon nitride Si3N4 powder is an inorganic substance with the chemical formula Si3N4. Si3N4 is an important structural ceramic material with high hardness, inherent lubricity, wear resistance, atomic crystallinity and high temperature oxidation res…

Global water reducer,water reducing agent ,concrete admixtures market trend 2023-2030 The formula and production method of water reducer for concrete by Newsbinaa-syria

The application of various concrete admixtures can not only improve the performance of concrete, but also promote the development of new concrete technologies, promote the application of industrial by-products in cementitious material systems, and al…

Global MnO2 powder market trend 2024-2029 What is Manganese Dioxide MnO2 Used For? by Newsbinaa-syria

According to statistics from China Chemical and Physical Power Supply Industry Association, China's export volume and export value of lithium-ion batteries have continued to increase. In 2021, China's exports of lithium-ion batteries were 3.428 billi…